Journal: Cells

Article Title: The miR-28-5p Targetome Discovery Identified SREBF2 as One of the Mediators of the miR-28-5p Tumor Suppressor Activity in Prostate Cancer Cells

doi: 10.3390/cells9020354

Figure Lengend Snippet: Association of miR-28-5p expression with clinical parameters in PCa patients. ( A ) Analysis of miR-28-5p expression level data of the Memorial Sloan Kettering Cancer Center (MSKCC) study’s patients. The significances according to the Kruskal–Wallis and Wilcoxon test are indicated. ( B ) Kaplan–Meier curves for recurrence-free survival events between MSKCC patients after dividing samples into two groups according to the 25st quartile of miR-28-5p expression level. Log-rank test’s p -value is shown. The miR-28-5p expression levels (log2RPMK) of TGCA PRAD samples are shown and grouped by pathological T stage ( C ) and Gleason score ( D ) with p -value from the Spearman’s test of association.

Article Snippet: For the correlation analysis between miR-28-5p expression level and Gleason score/Tumor T stage, The Cancer Genome Atlas (TCGA) Prostate Adenocarcinoma (PRAD) primary tumors ( n = 494) data were investigated from work by the Broad Institute TCGA Genome Data Analysis Center (2016) [ ].

Techniques: Expressing

Journal: Cell Reports Medicine

Article Title: Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer

doi: 10.1016/j.xcrm.2023.100937

Figure Lengend Snippet:

Article Snippet: Prostate cancer paraffin embedded tumor samples , Mount Sinai Medical Center and CHTN , N/A (see section for details) .

Techniques: Virus, Recombinant, SYBR Green Assay, Transfection, Luciferase, Sample Prep, Phospho-proteomics, Plasmid Preparation, Mutagenesis, Control, Software